Grupos controle de ensaios clínicos sobre intervenções não medicamentosas para dor oncológica: uma meta-pesquisa
DOI:
https://doi.org/10.15343/0104-7809.202650e18042025IPalavras-chave:
Dor do Câncer, Métodos Terapêuticos Complementares, Saúde HolísticaResumo
A dor oncológica é um desafio comum em pacientes com câncer, originada da progressão tumoral ou dos efeitos adversos dos tratamentos. Para seu manejo, intervenções não-farmacológicas têm sido estudadas por ensaios clínicos randomizados (ECR), que requerem estratégias comparativas adequadas (placebo ou sham) para isolar os efeitos da intervenção. Entretanto, a limitação do mascaramento nesse tipo de intervenção pode influenciar a interpretação dos resultados. O objetivo deste estudo foi identificar as estratégias utilizadas nos grupos controle de ensaios clínicos randomizados que avaliam intervenções não-farmacológicas para a dor oncológica. Trata-se de uma meta pesquisa (investigação sobre como a ciência é produzida) nas bases MEDLINE e LILACS, utilizando descritores MeSH/DeCS e termos livres relacionados a “Cancer pain” e “Complementary therapies”, sem restrição de idioma ou ano de publicação. Excluiu-se estudos não randomizados e aqueles que envolviam intervenções cirúrgicas. A seleção e a extração dos dados ocorreram em duplicata. Foram extraídos informações sobre tipo de mascaramento e estratégias utilizadas nos grupos controle. A busca recuperou 311 artigos, 52 foram incluídos após a seleção, dos quais 22 apresentaram texto completo disponível. Destes, 15 eram simples-cegos, 6 abertos, 1 descrito como duplo-cego e 12 discutiram o impacto do viés de performance. As intervenções mais avaliadas incluíram acupuntura, massagem terapêutica e musicoterapia. Os grupos controle variaram entre tratamento usual, placebo, ausência de intervenção e procedimentos simulados. Conclui-se que há grande variabilidade nas estratégias de controle, e que a ausência de discussão sobre viés de performance pode comprometer a interpretação dos resultados e a tomada de decisão clínica.
Downloads
Não há dados estatísticos.
Tradução
Este artigo é uma tradução em English do artigo:
Grupos controle de ensaios clínicos sobre intervenções não medicamentosas para dor oncológica: uma meta-pesquisa
Referências
Bradt J, Leader A, Worster B, Myers-Coffman K, Bryl K, Biondo J, et al. Music therapy for pain management for people with advanced cancer: a randomized controlled trial. Psychooncology. 2024;33(10):e70005. doi:10.1002/pon.70005.
Yang S, Park S, Shin J, Kim H, Kim H, Lim Y, et al. The modified WHO analgesic ladder: Is it appropriate for chronic non-cancer pain? J Pain Res. 2020;13:411–417. doi:10.2147/JPR.S244173.
Tian W, Zhang Y, Yu B, Jin H, Wang W, Yuan T, et al. Transcutaneous electrical acupoint stimulation for alleviating pain in patients with advanced pancreatic cancer. J Cancer Res Ther. 2024;20(4):1334–7. doi:10.4103/jcrt.jcrt_2172_23.
Ruela LO, Iunes DH, Nogueira DA, Stefanello J, Gradim CVC. Efetividade da acupuntura auricular no tratamento da dor oncológica: ensaio clínico randomizado. Rev Bras Enferm. 2017;70(4):807–13. doi:10.1590/S1980-220X2017040503402.
Weinrich SP, Weinrich MC. The effect of massage on pain in cancer patients. Appl Nurs Res. 1990;3(4):140–5.
Carson JW, Carson KM, Olsen MK, Sanders L, Westbrook K, Keefe FJ, et al. Yoga practice predicts improvements in day-to-day pain in women with metastatic breast cancer. J Pain Symptom Manage. 2021;61(6):1227–33.
Bandeira MD. Mascaramento em ensaios clínicos [Internet]. EME – Estudantes para Melhores Evidências; 2021 [citado 2025 maio 28]. Disponível em: https://eme.cochrane.org/mascaramento-em-ensaios-clinicos/
Johnson MI, Goebel A. Sham controls in device trials for chronic pain: tricky in practice. Pain Manag. 2023;13(6):423–6. doi:10.2217/pmt-2023-0032. Disponível em: https://pmc.ncbi.nlm.nih.gov/articles/PMC10474149/
Ioannidis JPA. Meta-research: why research on research matters. PLoS Biol. 2018;16(3):e2005468.
Lefebvre C, Glanville J, Briscoe S, Featherstone R, Littlewood A, Metzendorf MI, et al. Chapter 4: Searching for and selecting studies, section 4.4.3. In: Higgins JPT, Thomas J, Chandler J, Cumpston M, Li T, Page MJ, et al., editors. Cochrane Handbook for Systematic Reviews of Interventions. Version 6.5. London: Cochrane; 2024. Disponível em: https://www.cochrane.org/authors/handbooks-and-manuals/handbook/current/chapter-04#section-4-4-3.
Ouzzani M, Hammady H, Fedorowicz Z, Elmagarmid A. Rayyan: a web and mobile app for systematic reviews. Syst Rev. 2016;5:210. doi:10.1186/ s13643-016-0384-4.
Syrjala KL, Cummings C, Donaldson GW. Hypnosis or cognitive behavioral training for reduction of pain and nausea during cancer treatment: a controlled clinical trial. Pain. 1992;48(2):137–46. doi:10.1016/0304-3959(92)90049-H.
Ferrell-Torry AT, Glick OJ. The use of therapeutic massage as a nursing intervention to modify anxiety and perception of cancer pain. Cancer Nurs. 1993;16(2):93–101.
Syrjala KL, Donaldson GW, Davis MW, Kippes ME, Carr JE. Relaxation and imagery and cognitive-behavioral training reduce pain during cancer treatment: a controlled clinical trial. Pain. 1995;63(2):189–98. doi:10.1016/0304-3959(95)00039-U.
Reinhardt U. Untersuchungen zur Synchronisation von Herzfrequenz und musikalischem Rhythmus im Rahmen einer Entspannungstherapie bei Patienten mit tumorbedingten Schmerzen. Forsch Komplementarmed. 1999;6(3):135–41. doi:10.1159/000021235.
Wilkie DJ, Kampbell J, Cutshall S, Halabisky H, Harmon H, Johnson LP, et al. Effects of massage on pain intensity, analgesics, and quality of life in cancer pain: pilot randomized clinical trial conducted within hospice care delivery. Hosp J. 2000;15(3):31–53.
Olson K, Hanson J, Michaud M. A phase II trial of Reiki for management of pain in advanced cancer patients. J Pain Symptom Manage. 2003;26(5):990 7. doi:10.1016/s0885-3924(03)00334-8.
Alimi D, Rubino C, Pichard-Léandri E, Fermand-Brulé S, Dubreuil-Lemaire ML, Hill C. Analgesic effect of auricular acupuncture for cancer pain: randomized controlled trial. J Clin Oncol. 2003;21(22):4120–6. doi:10.1200/JCO.2003.09.011.
Siedliecki SL, Good M. Effect of music on power, pain, depression and disability. J Adv Nurs. 2006;54(5):553–62. doi:10.1111/j.1365-2648.2006.03860.x.
Zhang T, Ma SL, Xie GR, Deng QH, Tang ZZ, Pan XC, et al. Clinical research on nourishing yin and unblocking meridians recipe combined with opioid analgesics in cancer pain management. Chin J Integr Med. 2006;12(3):180–4. doi:10.1007/BF02836518.
Stephenson NL, Swanson M, Dalton J, Keefe FJ, Engelke M. Partner-delivered reflexology: effects on cancer pain and anxiety. Oncol Nurs Forum. 2007;34(1):127–32. doi:10.1188/07.ONF.127-132.
Tsai PS, Chen PL, Lai YL, Lee MB, Lin CC. Electromyography biofeedback-assisted relaxation on pain in advanced cancer patients in palliative care. Cancer Nurs. 2007;30(5):347–53. doi:10.1097/01.NCC.0000290805.38335.7b.
Chen ZJ, Guo YP, Wu ZC. Observation on therapeutic effect of acupuncture at pain points on cancer pain. Zhongguo Zhen Jiu. 2008;28(4):251–3.
Kwekkeboom KL, Wanta B, Bumpus M. Individual difference variables and effects of progressive muscle relaxation and analgesic imagery on cancer pain. J Pain Symptom Manage. 2008;36(6):604–15. doi:10.1016/j.jpainsymman.2007.12.011.
Butler LD, Koopman C, Neri E, Giese-Davis J, Palesh O, Thorne-Yocam KA, et al. Effects of supportive-expressive group therapy on pain in metastatic breast cancer. Health Psychol. 2009;28(5):579–87. doi:10.1037/a0016124.
Huang ST, Good M, Zauszniewski JA. Effectiveness of music in relieving pain in cancer patients. Int J Nurs Stud. 2010;47(11):1354–62. doi:10.1016/j. ijnurstu.2010.03.008.
Jane SW, Chen SL, Wilkie DJ, Lin YC, Foreman SW, Beaton RD, et al. Effects of massage on pain, mood, relaxation, and sleep in Taiwanese patients with metastatic bone pain. Pain. 2011;152(10):2432–42. doi:10.1016/j.pain.2011.06.021.
Chen H, Liu TY, Kuai L, Zhu J, Wu CJ, Liu LM. Electroacupuncture for pancreatic cancer pain: randomized controlled trial. Pancreatology. 2013;13(6):594–7. doi:10.1016/j.pan.2013.10.007.
Lee J, Yoon SW. Moxibustion for pain in metastatic cancer: pilot randomized single-blind trial. Integr Cancer Ther. 2014;13(3):211–6. doi:10.1177/1534735413510025.
Warth M, Keßler J, Hillecke TK, Bardenheuer HJ. Music therapy in palliative care. Dtsch Arztebl Int. 2015;112(46):788–94. doi:10.3238/ arztebl.2015.0788.
Sharif Nia H, Sharif SP, Yaghoobzadeh A, Yeoh KK, Goudarzian AH, Soleimani MA, et al. Effect of acupressure on pain in leukemia. Int J Nurs Pract. 2017;23(2):e12513. doi:10.1111/ijn.12513.
Uysal N, Kutlutürkan S, Uğur I. Effects of foot massage on symptom control in colorectal cancer. Int J Nurs Pract. 2017;23(3):e12532. doi:10.1111/ ijn.12532.
Lam TY, Lu LM, Ling WM, Lin LZ. Acupuncture at Si Guan Xue for cancer pain: pilot randomized controlled trial. BMC Complement Altern Med. 2017;17(1):335. doi:10.1186/s12906-017-1838-5.
Mendoza ME, Capafons A, Gralow JR, Syrjala KL, Suárez-Rodríguez JM, Fann JR, et al. Waking hypnosis plus CBT for pain, fatigue and sleep: randomized trial. Psychooncology. 2017;26(11):1832–8. doi:10.1002/pon.4232.
Xu L, Wan Y, Huang J, Xu F. Electroacupuncture and multiple acupoint stimulation for cancer pain in hepatocellular carcinoma. J Cancer Res Ther. 2018;14(1):99–102. doi:10.4103/jcrt.JCRT_736_17.
Eyigor S, Uslu R, Apaydın S, Caramat I, Yesil H. Yoga for shoulder/arm pain and QoL in breast cancer: randomized trial. Complement Ther Clin Pract. 2018;32:40–5. doi:10.1016/j.ctcp.2018.04.010.
Kim K, Lee S. Intradermal acupuncture plus analgesics for pain in advanced cancer. Integr Cancer Ther. 2018;17(4):1137–43. doi:10.1177/1534735418786797.
Liang Y, Bao G, Gong L, Zhou J, Kong X, Ran R, et al. TEAS + opioids for cancer pain: study protocol RCT. Trials. 2019;20(1):40. doi:10.1186/s13063 018-3145-y.
De Paolis G, Naccarato A, Cibelli F, D’Alete A, Mastroianni C, Surdo L, et al. Progressive muscle relaxation + imagery for cancer pain: multicentre RCT. Complement Ther Clin Pract. 2019;34:280–7. doi:10.1016/j.ctcp.2018.12.014.
Hsieh FC, Miao NF, Tseng IJ, Chiu HL, Kao CC, Liu D, et al. Music intervention vs ambient music in breast cancer survivors: feasibility study. Eur J Cancer Care. 2019;28(4):e13064. doi:10.1111/ecc.13064.
He Y, May BH, Zhang AL, Guo X, Liu Y, Qu Y, et al. Acupuncture for cancer pain: pilot RCT protocol. BMJ Open. 2019;9(7):e025564. doi:10.1136/ bmjopen-2018-025564.
Wu QL, Cao W, Wang W, Jiang ZY, Chen L, Li LL. Wrist-ankle needle + opioids for refractory cancer pain: RCT. Zhongguo Zhen Jiu. 2019;39(10):1051 4. doi:10.13703/j.0255-2930.2019.10.005.
Rambod M, Pasyar N, Shamsadini M. Foot reflexology for fatigue, pain and sleep in lymphoma: clinical trial. Eur J Oncol Nurs. 2019;43:101678. doi:10.1016/j.ejon.2019.101678.
Li D, Sun RR, Li QL, et al. Acupuncture + opioids for moderate/severe cancer pain: RCT. Zhongguo Zhen Jiu. 2020;40(3):257–61. doi:10.13703/ j.0255-2930.20190311-k0001.
Lei Y, Duan Y, Wang J, Yu X, Deng S, Liu R, et al. Acupuncture + therapy for prostate cancer pain: protocol. Medicine (Baltimore). 2020;99(14):e19609. doi:10.1097/MD.0000000000019609.
Xu LP, Yang SL, Su SQ, Huang BX, Lan XM, Yao RJ. Wrist-ankle + auricular acupuncture: four-arm RCT. Complement Ther Clin Pract. 2020;39:101170. doi:10.1016/j.ctcp.2020.101170.
Han XC, Xing QZ, Li Y, Dong X, Ma XW, Zhang L, et al. [Título do artigo]. Zhen Ci Yan Jiu. 2020;45(10):845–50. doi:10.13702/j.1000-0607.200131.
Siemens W, Boehlke C, Bennett MI, Offner K, Becker G, Gaertner J. TENS for advanced cancer pain: randomized sham-controlled crossover trial. Support Care Cancer. 2020;28(11):5323–33. doi:10.1007/s00520-020-05370-8.
Lu DR, Xia YQ, Chen F, Wang NJ, He SQ, Wang F, et al. [Título do artigo]. Zhongguo Zhen Jiu. 2021;41(2):121–4. doi:10.13703 /j.0255-2930.20190320-0010.
Saraswati W, Wardani R, Suhatno S, Hartono P, Imandiri A. Electroacupuncture on pain, β-endorphin and QoL in cervical cancer: RCT. J Acupunct Meridian Stud. 2021;14(1):4–12. doi:10.51507/j.jams.2021.14.1.4.
Mao JJ, Liou KT, Baser RE, Bao T, Panageas KS, Romero SAD, et al. Electroacupuncture or auricular acupuncture vs usual care for chronic musculoskeletal pain in cancer survivors: PEACE RCT. JAMA Oncol. 2021;7(5):720–7. doi:10.1001/jamaoncol.2021.0310.
Carson JW, Carson KM, Olsen M, Sanders L, Westbrook K, Keefe FJ, et al. Yoga practice and day-to-day pain in metastatic breast cancer. J Pain Symptom Manage. 2021;61(6):1227–33. doi:10.1016/j.jpainsymman.2020.10.009.
Ji JF, Ge XX, Xu CM, Jiang Y, Gu JH, Wei GH, et al. [Title not provided]. Zhongguo Zhen Jiu. 2021;41(7):725–9. doi:10.13703/j.0255 2930.20200615-k0002.
Miladinia M, Voss JG, Molavynejad S, Malehi AS, Zarea K, Nouri EM, et al. Slow-stroke back massage vs music therapy for leukemia-related pain: RCT. JCO Oncol Pract. 2021;17(11):e1614–21. doi:10.1200/OP.21.00156.
He Y, Zhang H, Li Y, Long S, Xiao S, May BH, et al. Acupuncture + opioids for cancer pain: pilot pragmatic RCT. Acupunct Med. 2022;40(2):133–41. doi:10.1177/09645284211056016.
Amini K, Tahrekhani M. Spiritual care for fatigue and pain in chemotherapy: RCT. Holist Nurs Pract. 2022;36(6):335–43. doi:10.1097/ HNP.0000000000000527.
Wang H, Tan JB, Wang T, Liu XL, Bressington D, Zheng SL, et al. Breathing exercise for chronic pain in breast cancer survivors: protocol RCT. BMJ Open. 2022;12(12):e064358. doi:10.1136/bmjopen-2022-064358.
Utli H, Dinç M, Utli MDA. Acupressure or Reiki for pain and fatigue in palliative cancer: RCT. Explore. 2023;19(1):91–9. doi:10.1016/j. explore.2022.11.007.
Chen H, Wu WY, Xie ZM, Yang Z, Yang B, Tang DX. [Título do artigo]. Zhongguo Zhen Jiu. 2023;43(3):322–6. doi:10.13703/j.0255 2930.20220816-k0001.
Epstein AS, Liou KT, Romero SAD, Baser RE, Wong G, Xiao H, et al. Acupuncture vs massage for pain in advanced cancer: IMPACT RCT. JAMA Netw Open. 2023;6(11):e2342482. doi:10.1001/jamanetworkopen.2023.42482.
Lyu Z, Tian S, Bao G, Huang R, Gong L, Zhou J, et al. TEAS for cancer pain in opioid therapy: RCT. Support Care Cancer. 2023;32(1):16. doi:10.1007/ s00520-023-08240-1.
Martínez-Miranda P, Jiménez-Rejano JJ, Muñoz-Fernández MJ, García-Muñoz C, Casuso-Holgado MJ. Online group intervention based on pain neuroscience + graded exposure in breast cancer survivors with chronic pain: RCT. Support Care Cancer. 2024;32(10):705. doi:10.1007/s00520-024 08887-4.
Yang S, Park S, Shin J, Kim H, Kim H, Lim Y, et al. The modified WHO analgesic ladder: Is it appropriate for chronic non-cancer pain? J Pain Res. 2020;13:411–417. doi:10.2147/JPR.S244173.
Tian W, Zhang Y, Yu B, Jin H, Wang W, Yuan T, et al. Transcutaneous electrical acupoint stimulation for alleviating pain in patients with advanced pancreatic cancer. J Cancer Res Ther. 2024;20(4):1334–7. doi:10.4103/jcrt.jcrt_2172_23.
Ruela LO, Iunes DH, Nogueira DA, Stefanello J, Gradim CVC. Efetividade da acupuntura auricular no tratamento da dor oncológica: ensaio clínico randomizado. Rev Bras Enferm. 2017;70(4):807–13. doi:10.1590/S1980-220X2017040503402.
Weinrich SP, Weinrich MC. The effect of massage on pain in cancer patients. Appl Nurs Res. 1990;3(4):140–5.
Carson JW, Carson KM, Olsen MK, Sanders L, Westbrook K, Keefe FJ, et al. Yoga practice predicts improvements in day-to-day pain in women with metastatic breast cancer. J Pain Symptom Manage. 2021;61(6):1227–33.
Bandeira MD. Mascaramento em ensaios clínicos [Internet]. EME – Estudantes para Melhores Evidências; 2021 [citado 2025 maio 28]. Disponível em: https://eme.cochrane.org/mascaramento-em-ensaios-clinicos/
Johnson MI, Goebel A. Sham controls in device trials for chronic pain: tricky in practice. Pain Manag. 2023;13(6):423–6. doi:10.2217/pmt-2023-0032. Disponível em: https://pmc.ncbi.nlm.nih.gov/articles/PMC10474149/
Ioannidis JPA. Meta-research: why research on research matters. PLoS Biol. 2018;16(3):e2005468.
Lefebvre C, Glanville J, Briscoe S, Featherstone R, Littlewood A, Metzendorf MI, et al. Chapter 4: Searching for and selecting studies, section 4.4.3. In: Higgins JPT, Thomas J, Chandler J, Cumpston M, Li T, Page MJ, et al., editors. Cochrane Handbook for Systematic Reviews of Interventions. Version 6.5. London: Cochrane; 2024. Disponível em: https://www.cochrane.org/authors/handbooks-and-manuals/handbook/current/chapter-04#section-4-4-3.
Ouzzani M, Hammady H, Fedorowicz Z, Elmagarmid A. Rayyan: a web and mobile app for systematic reviews. Syst Rev. 2016;5:210. doi:10.1186/ s13643-016-0384-4.
Syrjala KL, Cummings C, Donaldson GW. Hypnosis or cognitive behavioral training for reduction of pain and nausea during cancer treatment: a controlled clinical trial. Pain. 1992;48(2):137–46. doi:10.1016/0304-3959(92)90049-H.
Ferrell-Torry AT, Glick OJ. The use of therapeutic massage as a nursing intervention to modify anxiety and perception of cancer pain. Cancer Nurs. 1993;16(2):93–101.
Syrjala KL, Donaldson GW, Davis MW, Kippes ME, Carr JE. Relaxation and imagery and cognitive-behavioral training reduce pain during cancer treatment: a controlled clinical trial. Pain. 1995;63(2):189–98. doi:10.1016/0304-3959(95)00039-U.
Reinhardt U. Untersuchungen zur Synchronisation von Herzfrequenz und musikalischem Rhythmus im Rahmen einer Entspannungstherapie bei Patienten mit tumorbedingten Schmerzen. Forsch Komplementarmed. 1999;6(3):135–41. doi:10.1159/000021235.
Wilkie DJ, Kampbell J, Cutshall S, Halabisky H, Harmon H, Johnson LP, et al. Effects of massage on pain intensity, analgesics, and quality of life in cancer pain: pilot randomized clinical trial conducted within hospice care delivery. Hosp J. 2000;15(3):31–53.
Olson K, Hanson J, Michaud M. A phase II trial of Reiki for management of pain in advanced cancer patients. J Pain Symptom Manage. 2003;26(5):990 7. doi:10.1016/s0885-3924(03)00334-8.
Alimi D, Rubino C, Pichard-Léandri E, Fermand-Brulé S, Dubreuil-Lemaire ML, Hill C. Analgesic effect of auricular acupuncture for cancer pain: randomized controlled trial. J Clin Oncol. 2003;21(22):4120–6. doi:10.1200/JCO.2003.09.011.
Siedliecki SL, Good M. Effect of music on power, pain, depression and disability. J Adv Nurs. 2006;54(5):553–62. doi:10.1111/j.1365-2648.2006.03860.x.
Zhang T, Ma SL, Xie GR, Deng QH, Tang ZZ, Pan XC, et al. Clinical research on nourishing yin and unblocking meridians recipe combined with opioid analgesics in cancer pain management. Chin J Integr Med. 2006;12(3):180–4. doi:10.1007/BF02836518.
Stephenson NL, Swanson M, Dalton J, Keefe FJ, Engelke M. Partner-delivered reflexology: effects on cancer pain and anxiety. Oncol Nurs Forum. 2007;34(1):127–32. doi:10.1188/07.ONF.127-132.
Tsai PS, Chen PL, Lai YL, Lee MB, Lin CC. Electromyography biofeedback-assisted relaxation on pain in advanced cancer patients in palliative care. Cancer Nurs. 2007;30(5):347–53. doi:10.1097/01.NCC.0000290805.38335.7b.
Chen ZJ, Guo YP, Wu ZC. Observation on therapeutic effect of acupuncture at pain points on cancer pain. Zhongguo Zhen Jiu. 2008;28(4):251–3.
Kwekkeboom KL, Wanta B, Bumpus M. Individual difference variables and effects of progressive muscle relaxation and analgesic imagery on cancer pain. J Pain Symptom Manage. 2008;36(6):604–15. doi:10.1016/j.jpainsymman.2007.12.011.
Butler LD, Koopman C, Neri E, Giese-Davis J, Palesh O, Thorne-Yocam KA, et al. Effects of supportive-expressive group therapy on pain in metastatic breast cancer. Health Psychol. 2009;28(5):579–87. doi:10.1037/a0016124.
Huang ST, Good M, Zauszniewski JA. Effectiveness of music in relieving pain in cancer patients. Int J Nurs Stud. 2010;47(11):1354–62. doi:10.1016/j. ijnurstu.2010.03.008.
Jane SW, Chen SL, Wilkie DJ, Lin YC, Foreman SW, Beaton RD, et al. Effects of massage on pain, mood, relaxation, and sleep in Taiwanese patients with metastatic bone pain. Pain. 2011;152(10):2432–42. doi:10.1016/j.pain.2011.06.021.
Chen H, Liu TY, Kuai L, Zhu J, Wu CJ, Liu LM. Electroacupuncture for pancreatic cancer pain: randomized controlled trial. Pancreatology. 2013;13(6):594–7. doi:10.1016/j.pan.2013.10.007.
Lee J, Yoon SW. Moxibustion for pain in metastatic cancer: pilot randomized single-blind trial. Integr Cancer Ther. 2014;13(3):211–6. doi:10.1177/1534735413510025.
Warth M, Keßler J, Hillecke TK, Bardenheuer HJ. Music therapy in palliative care. Dtsch Arztebl Int. 2015;112(46):788–94. doi:10.3238/ arztebl.2015.0788.
Sharif Nia H, Sharif SP, Yaghoobzadeh A, Yeoh KK, Goudarzian AH, Soleimani MA, et al. Effect of acupressure on pain in leukemia. Int J Nurs Pract. 2017;23(2):e12513. doi:10.1111/ijn.12513.
Uysal N, Kutlutürkan S, Uğur I. Effects of foot massage on symptom control in colorectal cancer. Int J Nurs Pract. 2017;23(3):e12532. doi:10.1111/ ijn.12532.
Lam TY, Lu LM, Ling WM, Lin LZ. Acupuncture at Si Guan Xue for cancer pain: pilot randomized controlled trial. BMC Complement Altern Med. 2017;17(1):335. doi:10.1186/s12906-017-1838-5.
Mendoza ME, Capafons A, Gralow JR, Syrjala KL, Suárez-Rodríguez JM, Fann JR, et al. Waking hypnosis plus CBT for pain, fatigue and sleep: randomized trial. Psychooncology. 2017;26(11):1832–8. doi:10.1002/pon.4232.
Xu L, Wan Y, Huang J, Xu F. Electroacupuncture and multiple acupoint stimulation for cancer pain in hepatocellular carcinoma. J Cancer Res Ther. 2018;14(1):99–102. doi:10.4103/jcrt.JCRT_736_17.
Eyigor S, Uslu R, Apaydın S, Caramat I, Yesil H. Yoga for shoulder/arm pain and QoL in breast cancer: randomized trial. Complement Ther Clin Pract. 2018;32:40–5. doi:10.1016/j.ctcp.2018.04.010.
Kim K, Lee S. Intradermal acupuncture plus analgesics for pain in advanced cancer. Integr Cancer Ther. 2018;17(4):1137–43. doi:10.1177/1534735418786797.
Liang Y, Bao G, Gong L, Zhou J, Kong X, Ran R, et al. TEAS + opioids for cancer pain: study protocol RCT. Trials. 2019;20(1):40. doi:10.1186/s13063 018-3145-y.
De Paolis G, Naccarato A, Cibelli F, D’Alete A, Mastroianni C, Surdo L, et al. Progressive muscle relaxation + imagery for cancer pain: multicentre RCT. Complement Ther Clin Pract. 2019;34:280–7. doi:10.1016/j.ctcp.2018.12.014.
Hsieh FC, Miao NF, Tseng IJ, Chiu HL, Kao CC, Liu D, et al. Music intervention vs ambient music in breast cancer survivors: feasibility study. Eur J Cancer Care. 2019;28(4):e13064. doi:10.1111/ecc.13064.
He Y, May BH, Zhang AL, Guo X, Liu Y, Qu Y, et al. Acupuncture for cancer pain: pilot RCT protocol. BMJ Open. 2019;9(7):e025564. doi:10.1136/ bmjopen-2018-025564.
Wu QL, Cao W, Wang W, Jiang ZY, Chen L, Li LL. Wrist-ankle needle + opioids for refractory cancer pain: RCT. Zhongguo Zhen Jiu. 2019;39(10):1051 4. doi:10.13703/j.0255-2930.2019.10.005.
Rambod M, Pasyar N, Shamsadini M. Foot reflexology for fatigue, pain and sleep in lymphoma: clinical trial. Eur J Oncol Nurs. 2019;43:101678. doi:10.1016/j.ejon.2019.101678.
Li D, Sun RR, Li QL, et al. Acupuncture + opioids for moderate/severe cancer pain: RCT. Zhongguo Zhen Jiu. 2020;40(3):257–61. doi:10.13703/ j.0255-2930.20190311-k0001.
Lei Y, Duan Y, Wang J, Yu X, Deng S, Liu R, et al. Acupuncture + therapy for prostate cancer pain: protocol. Medicine (Baltimore). 2020;99(14):e19609. doi:10.1097/MD.0000000000019609.
Xu LP, Yang SL, Su SQ, Huang BX, Lan XM, Yao RJ. Wrist-ankle + auricular acupuncture: four-arm RCT. Complement Ther Clin Pract. 2020;39:101170. doi:10.1016/j.ctcp.2020.101170.
Han XC, Xing QZ, Li Y, Dong X, Ma XW, Zhang L, et al. [Título do artigo]. Zhen Ci Yan Jiu. 2020;45(10):845–50. doi:10.13702/j.1000-0607.200131.
Siemens W, Boehlke C, Bennett MI, Offner K, Becker G, Gaertner J. TENS for advanced cancer pain: randomized sham-controlled crossover trial. Support Care Cancer. 2020;28(11):5323–33. doi:10.1007/s00520-020-05370-8.
Lu DR, Xia YQ, Chen F, Wang NJ, He SQ, Wang F, et al. [Título do artigo]. Zhongguo Zhen Jiu. 2021;41(2):121–4. doi:10.13703 /j.0255-2930.20190320-0010.
Saraswati W, Wardani R, Suhatno S, Hartono P, Imandiri A. Electroacupuncture on pain, β-endorphin and QoL in cervical cancer: RCT. J Acupunct Meridian Stud. 2021;14(1):4–12. doi:10.51507/j.jams.2021.14.1.4.
Mao JJ, Liou KT, Baser RE, Bao T, Panageas KS, Romero SAD, et al. Electroacupuncture or auricular acupuncture vs usual care for chronic musculoskeletal pain in cancer survivors: PEACE RCT. JAMA Oncol. 2021;7(5):720–7. doi:10.1001/jamaoncol.2021.0310.
Carson JW, Carson KM, Olsen M, Sanders L, Westbrook K, Keefe FJ, et al. Yoga practice and day-to-day pain in metastatic breast cancer. J Pain Symptom Manage. 2021;61(6):1227–33. doi:10.1016/j.jpainsymman.2020.10.009.
Ji JF, Ge XX, Xu CM, Jiang Y, Gu JH, Wei GH, et al. [Title not provided]. Zhongguo Zhen Jiu. 2021;41(7):725–9. doi:10.13703/j.0255 2930.20200615-k0002.
Miladinia M, Voss JG, Molavynejad S, Malehi AS, Zarea K, Nouri EM, et al. Slow-stroke back massage vs music therapy for leukemia-related pain: RCT. JCO Oncol Pract. 2021;17(11):e1614–21. doi:10.1200/OP.21.00156.
He Y, Zhang H, Li Y, Long S, Xiao S, May BH, et al. Acupuncture + opioids for cancer pain: pilot pragmatic RCT. Acupunct Med. 2022;40(2):133–41. doi:10.1177/09645284211056016.
Amini K, Tahrekhani M. Spiritual care for fatigue and pain in chemotherapy: RCT. Holist Nurs Pract. 2022;36(6):335–43. doi:10.1097/ HNP.0000000000000527.
Wang H, Tan JB, Wang T, Liu XL, Bressington D, Zheng SL, et al. Breathing exercise for chronic pain in breast cancer survivors: protocol RCT. BMJ Open. 2022;12(12):e064358. doi:10.1136/bmjopen-2022-064358.
Utli H, Dinç M, Utli MDA. Acupressure or Reiki for pain and fatigue in palliative cancer: RCT. Explore. 2023;19(1):91–9. doi:10.1016/j. explore.2022.11.007.
Chen H, Wu WY, Xie ZM, Yang Z, Yang B, Tang DX. [Título do artigo]. Zhongguo Zhen Jiu. 2023;43(3):322–6. doi:10.13703/j.0255 2930.20220816-k0001.
Epstein AS, Liou KT, Romero SAD, Baser RE, Wong G, Xiao H, et al. Acupuncture vs massage for pain in advanced cancer: IMPACT RCT. JAMA Netw Open. 2023;6(11):e2342482. doi:10.1001/jamanetworkopen.2023.42482.
Lyu Z, Tian S, Bao G, Huang R, Gong L, Zhou J, et al. TEAS for cancer pain in opioid therapy: RCT. Support Care Cancer. 2023;32(1):16. doi:10.1007/ s00520-023-08240-1.
Martínez-Miranda P, Jiménez-Rejano JJ, Muñoz-Fernández MJ, García-Muñoz C, Casuso-Holgado MJ. Online group intervention based on pain neuroscience + graded exposure in breast cancer survivors with chronic pain: RCT. Support Care Cancer. 2024;32(10):705. doi:10.1007/s00520-024 08887-4.
Downloads
Publicado
2026-01-16
Como Citar
Gurman, N., Maruyama, A. T., Castagna, C., Moraes, R. C. G. de, Santos, S. S., Frederico, Y., & Latorraca, C. de O. C. (2026). Grupos controle de ensaios clínicos sobre intervenções não medicamentosas para dor oncológica: uma meta-pesquisa. O Mundo Da Saúde, 50. https://doi.org/10.15343/0104-7809.202650e18042025I
Edição
Seção
Artigos
Licença
Copyright (c) 2026 O Mundo da Saúde
Este trabalho está licenciado sob uma licença Creative Commons Attribution 4.0 International License.
.jpg)
