Ultrassom terapêutico altera as propriedades físico-químicas de carreadores lipídicos nanoestruturados
DOI:
https://doi.org/10.15343/0104-7809.202549e17162025PPalavras-chave:
Terapia por Ultrassom, Sistemas de Liberação de Fármacos por Nanopartículas, QuercetinaResumo
A quercetina tem potencial terapêutico na recuperação de lesões musculoesqueléticas, mas, por via oral, esse polifenol apresenta baixa absorção. Sua penetração na pele pode ser potencializada por carreadores lipídicos nanoestruturados carregados com quercetina (NLC-Q) aplicados em associação com o ultrassom terapêutico pulsado (PTU). No entanto, diferentes intensidades do ultrassom de 1 MHz podem comprometer as propriedades físico-químicas das NLC-Q, porém esta interação ainda não foi avaliada. O objetivo desta pesquisa foi avaliar os efeitos de diferentes intensidades do PTU de 1 MHz nas propriedades físico-químicas de um gel contendo carreadores lipídicos nanoestruturados carregados com quercetina (NLC-Q). As NLC-Q foram desenvolvidas pelo método de alta taxa de cisalhamento. O PTU (1 MHz, por 5 min, ciclo de trabalho de 20%) foi aplicado ao gel nas intensidades de 0,1, 0,2, 0,4 e 0,6 W/ cm2 SATA (intensidade espacial média-temporal). As propriedades físico-químicas (pH, temperatura, tamanho médio das partículas, índice de polidispersão e as concentrações de quercetina contidas nos carreadores lipídicos nanoestruturados) foram avaliados antes e após as aplicações das diferentes intensidades do PTU. As intensidades de 0,1 e 0,2 W/cm2 SATA não alteraram as propriedades físico-químicas das NLC-Q, enquanto as intensidades de 0,4 e 0,6 W/cm2 SATA aumentaram o tamanho das partículas respectivamente em 14% e 44% (P < 0,001). Essas intensidades também aumentaram o índice de polidispersão em 28% e 88% (P < 0,001). Intensidades maiores que 0,4 W/cm2 SATA do PTU promovem a instabilidade das NLC-Q contido no gel, o que não favorece a administração tópica do ingrediente ativo.
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