Evaluation of potential drug interactions in hospitalized pediatric oncology patients

DOI: 10.15343/0104-7809.202145034044

Authors

  • Emanuella de Souza Ribeiro Universidade Federal do Vale do São Francisco- UNIVASF. Pernambuco, Brasil.
  • Sybelle Christianne Batista de Lacerda Pedrosa Universidade Federal do Vale do São Francisco- UNIVASF. Pernambuco, Brasil.

Keywords:

Antineoplastics. Cancer. Pharmacotherapy. Oncology.

Abstract

Cancer is a disease characterized by the disordered growth of cells capable of invading adjacent tissues. In pediatric oncology, drug-drug interactions occur mainly with supportive drugs prescribed during treatment. Thus, the present study aims to identify and evaluate the potential drug-drug interactions (PDDIs) in hospitalized pediatric oncology patients. 203 prescriptions of 47 patients were analyzed. A total of 55 PDDIs were identified, with 14 different PDDIs, and 1.2 PDDI per patient. The most prevalent 47.2% (n = 26) was methotrexate and cotrimoxazole. 21 types of neoplasms were identified, the most frequent being acute lymphoblastic leukemia (ALL). The Spearman correlation was +0.71 (p<0.001), indicating a strong correlation with the occurrence of potential drug-drug interactions and the number of drugs prescribed. In the multivariate logistic regression analysis, the results showed that having ALL and polypharmacy were the main associated factors for the occurrence of PDDI. The probability of the occurrence of PDDIs increases by 9.7 times in polymedicated patients (95%CI = 4.6-21.4 (p=0.001)) and 12.1 times in ALL patients compared to those without ALL (95% CI=5.8-26.9 (p = 0.001)). In this perspective, the data obtained make it possible to provide subsidies for the implementation of strategies to monitor and provide clinical interventions that guarantee a more effective treatment, contributing to the safety of pediatric oncology patients.

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Published

2021-02-23

How to Cite

de Souza Ribeiro, E. ., & Christianne Batista de Lacerda Pedrosa, S. (2021). Evaluation of potential drug interactions in hospitalized pediatric oncology patients: DOI: 10.15343/0104-7809.202145034044. O Mundo Da Saúde, 45, 034–044. Retrieved from https://revistamundodasaude.emnuvens.com.br/mundodasaude/article/view/1012