Avaliação da tipagem sanguínea em pacientes com câncer de mama em centro de oncologia do Agreste Pernambucano
DOI: 10.15343/0104-7809.202044565571
Palabras clave:
Tipagem sanguínea. Câncer de mama. Sistema ABO. Fator de risco.Resumen
Desde o primeiro relato de associação entre o antígeno A e o aumento de risco de câncer de estômago, diversos estudos
têm avaliado o envolvimento do grupo sanguíneo ABO na patogênese do câncer. Baseando-se nesta hipótese, este estudo
objetivou associar a tipagem sanguínea como fator de risco para desenvolvimento do câncer de mama em uma população
feminina atendida no Centro de Oncologia de Caruaru (CEOC) em Pernambuco. O grupo ‘casos’ (n=50) foi composto de
pacientes do sexo feminino diagnosticadas com câncer de mama com grupo sanguíneo ABO sorologicamente confirmado.
O grupo ‘controles’ (n=50) foi obtido através de prontuários eletrônicos de pacientes sem o diagnóstico de câncer, com
a mesma faixa etária. A frequência de distribuição dos grupos sanguíneos foi comparada entre os casos (48% O, 40% A,
12% B e 0% AB) e controles (44% O, 40% A, 14% B e 02% AB). Os achados deste estudo mostraram que não houve
associação significativa entre câncer de mama e grupo sanguíneo ABO (p>0,05), além de não terem sido observadas
diferenças significativas nas características clinicas entre pacientes com diferentes tipos do grupo sanguíneo ABO.
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Citas
1. Miao SY, Zhou W, Chen L, Wang S, Liu XA. Influence of ABO blood group and Rhesus factor on breast cancer risk: A meta-analysis
of 9665 breast cancer patients and 244768 controls. Asia Pac J Clin Oncol. 2014; 10(2): 101–8. doi: 10.1111/ajco.12083
2. Wolpin BM, Chan AT, Hartge P, Chanock SJ, Kraft P, Hunter DJ, et al. ABO blood group and the risk of pancreatic cancer. J Natl
Cancer Inst. 2009; 101(6): 424–31. doi: 10.1093/jnci/djp020
3. Ben Q, Wang K, Yuan Y, Li Z. Pancreatic cancer incidence and outcome in relation to ABO blood groups among Han Chinese
patients: A case-control study. Int J Cancer. 2011; 128(5): 1179–86. doi: 10.1002/ijc.25426
4. Poole EM, Gates MA, High BA, Chanock SJ, Cramer DW, Cunningham JM, et al. ABO blood group and risk of epithelial ovarian
cancer within the Ovarian Cancer Association Consortium. Cancer Causes Control. 2012; 23(11):1805–10. doi: 10.1007/s10552-012-
0059-y.
5. INCA. Estimativa 2018. Incidência de câncer no Brasil. Instituto Nacional de Câncer José Alencar Gomes da Silva. 2017. 130 p. doi:
978-85-7318-283-5
6. Brasil. Cadernos de Atenção Básica: CCU e CA de Mama. 2013. doi: 10.1007/s13398-014-0173-7.2
7. Edgren G, Hjalgrim H, Rostgaard K, Norda R, Wikman A, Melbye M, et al. Risk of gastric cancer and peptic ulcers in relation to ABO
blood type: A cohort study. Am J Epidemiol. 2010; 172(11): 1280–5. doi: 10.1093/aje/kwq299
8. Stamatakos M, Kontzoglou K, Safioleas P, Safioleas C, Manti C, Safioleas M. Breast cancer incidence in Greek women in relation to
ABO blood groups and Rh factor. Int Semin Surg Oncol. 2009; 6(14): 1-5. doi: 10.1186/1477-7800-6-14
9. Park S, Kim KS, Kim JS, Han W, Park BW, Lee S, et al. Prognostic value of ABO blood types in young patients with breast cancer; a
nationwide study in Korean Breast Cancer Society. Med Oncol. 2017; 34(6). doi: 10.1007/s12032-017-0974-6
10. Urun Y, Utkan G, Altundag K, Arslan O, Onur H, Arslan UY, et al. ABO and Rh blood groups frequency in women with HER2
positive breast câncer. J BUON. 2012; 17(3): 457-460. PMID: 23033281
11. Klimant E, Glurich I, Mukesh B, Onitilo AA. Blood type, hormone receptor status, HER2/neu status, and survival in breast cancer:
A retrospective study exploring relationships in a phenotypically well-defined cohort. Clin Med Res. 2011; 9(3-4): 111-8. doi: 10.3121/
cmr.2011.907
12. Soro anti-A, anti-B, anti-AB: anticorpos monoclonais para tipagem sanguínea. Resp. Téc.: Dra.Nadjara Novaes Longen. São Paulo
(SP): Ebram Produtos Laboratoriais Ltda, 2016.
13. Bothou A, Tsikouras P, Zervoudis S, Tsatsaris G, Anastasopoulos G, Latrakis G, et al. Bloof groups type linked to breast cancer in a
Greek cohort of women – a case control study. J BUON. 2019; 24 (5); 1884-8. PMID: 31786851
14. Rummel SK, Ellswhorth RE. The role of the histoblood ABO group in cancer. Future Sci OA. 2016;2(2). doi: 10.4155/fsoa-2015-0012
15. Franchini M, Lippi G. The intriguing relationship between the ABO blood group, cardiovascular disease, and cancer. BMC Med.
2015; 13:7. doi: 10.1186/s12916- 014-0250-y
16. Aird I, Benatll HH, Roberts JAF. Relationshio Between Cancer of Stomach and the ABO Blood Groups. Br Med J. 1953; 1(4814):799-801. doi: 10.1136/bmj.1.4814799
17. Aly R, Yousef A, Elbably O. Association of ABO Blood Group and Risk of Breast Cancer. J Blood Disords Transf. 2014; 5: 9. doi:
10.4172/2155-9864.1000241
18. Akin S, Altundag K. Clinical Associations with ABO Blood Group and Rhesus Blood Group Status in Patients with Breast Cancer:
A Nationwide Retrospective Study of 3,944 Breast Cancer Patients in Turkey. Med Sci Monit. 2018; 24: 4698- 4703. doi: 10.12659/
MSM.909499
19. Pendu JL, Marionneau S, Cailleau-Thomas A, Rocher J, Moullac-Vaidye BL, Clément B. ABH and Lewis histo-blood group antigens
in cancer. Apmis. 2001;109 (1): 9–31. doi: 10.1111/j.1600-0463.2001.tb00011.x
20. Liumbruno GM, Franchini M. Hemostasis, cancer, and ABO blood group: The most recent evidence of association. J Thromb
Thrombolysis. 2014; 38(2): 160–6. doi: 10.1007/s11239-013-1027-4
21. Yu J, Gao F, Klimberg SV, Margenthaler JA. ABO blood type/Rh factor and the incidence and outcomes for patients with triplenegative
breast cancer. Ann Surg Oncol. 2012; 19(10): 3159–64. doi: 10.1245/s10434-012-2533-x
22. Gates MA, Xu M, Chen WY, Kraft P, Hankinson SE, Wolpin BM. ABO blood group and breast cancer incidence and survival. Int J
Cancer. 2012; 130(9): 2129- 37. doi: 10.1002/ijc.26220
23. Flavarjani AHM, Hedayatpour B, Bashardoost N, Nourian SM. Study of the association between blood types and breast cancer
among Isfahanian women with breast cancer. Adv Biomed Res. 2014; 3:43. doi: 10.4103/2277-9175.125749
24. Meo AS. Blood Groups and Breast Cancer. Pak J Med Sci. 2018; 34(6): 1589. doi: 10.12669/pjms.346.16824.
25. Meo SA, Suraya F, Jamil B, Rouq FA, Meo AS, Sattar K, Ansari M, et al. Association of ABO Blood Group and Risk of Breast Cancer.
Saudi J Biol Sci. 2017; 24(7): doi: 10.1016/j.sjbs.2017.01.058
26. Vasan SK, Hwang J, Rostgaard K, Nyrén O, Ullum H, Pedersen OBV, et al. ABO blood group and risk of cancer: A register-based
cohort study of 1.6 million blood donors. Cancer Epidemiol. 2016; 44: 40–3. doi: 10.1016/j.canep.2016.06.005
27. Zouine S, Marnissi F, Otmani N, Othmani MB, Wafi ME, Kojok K, et al. ABO blood groups in relation to breast carcinoma incidence
and associated prognostic factors in Moroccan women. Med Oncol. 2016; 33(7). doi: 10.1007/s12032-016-0784-2
Received
of 9665 breast cancer patients and 244768 controls. Asia Pac J Clin Oncol. 2014; 10(2): 101–8. doi: 10.1111/ajco.12083
2. Wolpin BM, Chan AT, Hartge P, Chanock SJ, Kraft P, Hunter DJ, et al. ABO blood group and the risk of pancreatic cancer. J Natl
Cancer Inst. 2009; 101(6): 424–31. doi: 10.1093/jnci/djp020
3. Ben Q, Wang K, Yuan Y, Li Z. Pancreatic cancer incidence and outcome in relation to ABO blood groups among Han Chinese
patients: A case-control study. Int J Cancer. 2011; 128(5): 1179–86. doi: 10.1002/ijc.25426
4. Poole EM, Gates MA, High BA, Chanock SJ, Cramer DW, Cunningham JM, et al. ABO blood group and risk of epithelial ovarian
cancer within the Ovarian Cancer Association Consortium. Cancer Causes Control. 2012; 23(11):1805–10. doi: 10.1007/s10552-012-
0059-y.
5. INCA. Estimativa 2018. Incidência de câncer no Brasil. Instituto Nacional de Câncer José Alencar Gomes da Silva. 2017. 130 p. doi:
978-85-7318-283-5
6. Brasil. Cadernos de Atenção Básica: CCU e CA de Mama. 2013. doi: 10.1007/s13398-014-0173-7.2
7. Edgren G, Hjalgrim H, Rostgaard K, Norda R, Wikman A, Melbye M, et al. Risk of gastric cancer and peptic ulcers in relation to ABO
blood type: A cohort study. Am J Epidemiol. 2010; 172(11): 1280–5. doi: 10.1093/aje/kwq299
8. Stamatakos M, Kontzoglou K, Safioleas P, Safioleas C, Manti C, Safioleas M. Breast cancer incidence in Greek women in relation to
ABO blood groups and Rh factor. Int Semin Surg Oncol. 2009; 6(14): 1-5. doi: 10.1186/1477-7800-6-14
9. Park S, Kim KS, Kim JS, Han W, Park BW, Lee S, et al. Prognostic value of ABO blood types in young patients with breast cancer; a
nationwide study in Korean Breast Cancer Society. Med Oncol. 2017; 34(6). doi: 10.1007/s12032-017-0974-6
10. Urun Y, Utkan G, Altundag K, Arslan O, Onur H, Arslan UY, et al. ABO and Rh blood groups frequency in women with HER2
positive breast câncer. J BUON. 2012; 17(3): 457-460. PMID: 23033281
11. Klimant E, Glurich I, Mukesh B, Onitilo AA. Blood type, hormone receptor status, HER2/neu status, and survival in breast cancer:
A retrospective study exploring relationships in a phenotypically well-defined cohort. Clin Med Res. 2011; 9(3-4): 111-8. doi: 10.3121/
cmr.2011.907
12. Soro anti-A, anti-B, anti-AB: anticorpos monoclonais para tipagem sanguínea. Resp. Téc.: Dra.Nadjara Novaes Longen. São Paulo
(SP): Ebram Produtos Laboratoriais Ltda, 2016.
13. Bothou A, Tsikouras P, Zervoudis S, Tsatsaris G, Anastasopoulos G, Latrakis G, et al. Bloof groups type linked to breast cancer in a
Greek cohort of women – a case control study. J BUON. 2019; 24 (5); 1884-8. PMID: 31786851
14. Rummel SK, Ellswhorth RE. The role of the histoblood ABO group in cancer. Future Sci OA. 2016;2(2). doi: 10.4155/fsoa-2015-0012
15. Franchini M, Lippi G. The intriguing relationship between the ABO blood group, cardiovascular disease, and cancer. BMC Med.
2015; 13:7. doi: 10.1186/s12916- 014-0250-y
16. Aird I, Benatll HH, Roberts JAF. Relationshio Between Cancer of Stomach and the ABO Blood Groups. Br Med J. 1953; 1(4814):799-801. doi: 10.1136/bmj.1.4814799
17. Aly R, Yousef A, Elbably O. Association of ABO Blood Group and Risk of Breast Cancer. J Blood Disords Transf. 2014; 5: 9. doi:
10.4172/2155-9864.1000241
18. Akin S, Altundag K. Clinical Associations with ABO Blood Group and Rhesus Blood Group Status in Patients with Breast Cancer:
A Nationwide Retrospective Study of 3,944 Breast Cancer Patients in Turkey. Med Sci Monit. 2018; 24: 4698- 4703. doi: 10.12659/
MSM.909499
19. Pendu JL, Marionneau S, Cailleau-Thomas A, Rocher J, Moullac-Vaidye BL, Clément B. ABH and Lewis histo-blood group antigens
in cancer. Apmis. 2001;109 (1): 9–31. doi: 10.1111/j.1600-0463.2001.tb00011.x
20. Liumbruno GM, Franchini M. Hemostasis, cancer, and ABO blood group: The most recent evidence of association. J Thromb
Thrombolysis. 2014; 38(2): 160–6. doi: 10.1007/s11239-013-1027-4
21. Yu J, Gao F, Klimberg SV, Margenthaler JA. ABO blood type/Rh factor and the incidence and outcomes for patients with triplenegative
breast cancer. Ann Surg Oncol. 2012; 19(10): 3159–64. doi: 10.1245/s10434-012-2533-x
22. Gates MA, Xu M, Chen WY, Kraft P, Hankinson SE, Wolpin BM. ABO blood group and breast cancer incidence and survival. Int J
Cancer. 2012; 130(9): 2129- 37. doi: 10.1002/ijc.26220
23. Flavarjani AHM, Hedayatpour B, Bashardoost N, Nourian SM. Study of the association between blood types and breast cancer
among Isfahanian women with breast cancer. Adv Biomed Res. 2014; 3:43. doi: 10.4103/2277-9175.125749
24. Meo AS. Blood Groups and Breast Cancer. Pak J Med Sci. 2018; 34(6): 1589. doi: 10.12669/pjms.346.16824.
25. Meo SA, Suraya F, Jamil B, Rouq FA, Meo AS, Sattar K, Ansari M, et al. Association of ABO Blood Group and Risk of Breast Cancer.
Saudi J Biol Sci. 2017; 24(7): doi: 10.1016/j.sjbs.2017.01.058
26. Vasan SK, Hwang J, Rostgaard K, Nyrén O, Ullum H, Pedersen OBV, et al. ABO blood group and risk of cancer: A register-based
cohort study of 1.6 million blood donors. Cancer Epidemiol. 2016; 44: 40–3. doi: 10.1016/j.canep.2016.06.005
27. Zouine S, Marnissi F, Otmani N, Othmani MB, Wafi ME, Kojok K, et al. ABO blood groups in relation to breast carcinoma incidence
and associated prognostic factors in Moroccan women. Med Oncol. 2016; 33(7). doi: 10.1007/s12032-016-0784-2
Received
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Publicado
2020-10-01
Cómo citar
de Oliveira Alves, W. ., Marinho Batista Tavares Filho, R. ., Rios de Larrazábal, B. ., Elaine Silva Germinio, J. ., Lucia Peres de Medeiros, A., & Andrade Martins Esteves, F. (2020). Avaliação da tipagem sanguínea em pacientes com câncer de mama em centro de oncologia do Agreste Pernambucano: DOI: 10.15343/0104-7809.202044565571. O Mundo Da Saúde, 44, 565–571. Recuperado a partir de https://revistamundodasaude.emnuvens.com.br/mundodasaude/article/view/992
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