Blood type evaluation in breast cancer patients at an oncology center in Agreste Pernambucano
DOI: 10.15343/0104-7809.202044565571
Keywords:
Blood typing. Breast cancer. ABO system. Risk factor.Abstract
Since the first report of an association between antigen A and the increased risk of stomach cancer, several studies have
evaluated the involvement of the ABO blood group in cancer pathogenesis. Based on this hypothesis, this study aimed to
identify blood typing as a risk factor for the development of breast cancer in a female population attended at the Oncology
Center of Caruaru (CEOC) in Pernambuco. The ‘case’ group (n=50) was comprised of female patients diagnosed with
breast cancer with a serologically confirmed ABO blood group. The ‘control’ group (n=50) was obtained from electronic
medical records of patients without a diagnosis of cancer, with the same age. The frequency of distribution of blood groups
was compared between cases (48% O, 40% A, 12% B, and 0% AB) and controls (44% O, 40% A, 14% B, and 2% AB).
The findings of this study showed that there was no significant association between breast cancer and ABO blood group
(p>0.05), in addition to the fact that no significant differences in clinical characteristics were observed between patients with
different types of ABO blood.
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References
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Greek cohort of women – a case control study. J BUON. 2019; 24 (5); 1884-8. PMID: 31786851
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17. Aly R, Yousef A, Elbably O. Association of ABO Blood Group and Risk of Breast Cancer. J Blood Disords Transf. 2014; 5: 9. doi:
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A Nationwide Retrospective Study of 3,944 Breast Cancer Patients in Turkey. Med Sci Monit. 2018; 24: 4698- 4703. doi: 10.12659/
MSM.909499
19. Pendu JL, Marionneau S, Cailleau-Thomas A, Rocher J, Moullac-Vaidye BL, Clément B. ABH and Lewis histo-blood group antigens
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Thrombolysis. 2014; 38(2): 160–6. doi: 10.1007/s11239-013-1027-4
21. Yu J, Gao F, Klimberg SV, Margenthaler JA. ABO blood type/Rh factor and the incidence and outcomes for patients with triplenegative
breast cancer. Ann Surg Oncol. 2012; 19(10): 3159–64. doi: 10.1245/s10434-012-2533-x
22. Gates MA, Xu M, Chen WY, Kraft P, Hankinson SE, Wolpin BM. ABO blood group and breast cancer incidence and survival. Int J
Cancer. 2012; 130(9): 2129- 37. doi: 10.1002/ijc.26220
23. Flavarjani AHM, Hedayatpour B, Bashardoost N, Nourian SM. Study of the association between blood types and breast cancer
among Isfahanian women with breast cancer. Adv Biomed Res. 2014; 3:43. doi: 10.4103/2277-9175.125749
24. Meo AS. Blood Groups and Breast Cancer. Pak J Med Sci. 2018; 34(6): 1589. doi: 10.12669/pjms.346.16824.
25. Meo SA, Suraya F, Jamil B, Rouq FA, Meo AS, Sattar K, Ansari M, et al. Association of ABO Blood Group and Risk of Breast Cancer.
Saudi J Biol Sci. 2017; 24(7): doi: 10.1016/j.sjbs.2017.01.058
26. Vasan SK, Hwang J, Rostgaard K, Nyrén O, Ullum H, Pedersen OBV, et al. ABO blood group and risk of cancer: A register-based
cohort study of 1.6 million blood donors. Cancer Epidemiol. 2016; 44: 40–3. doi: 10.1016/j.canep.2016.06.005
27. Zouine S, Marnissi F, Otmani N, Othmani MB, Wafi ME, Kojok K, et al. ABO blood groups in relation to breast carcinoma incidence
and associated prognostic factors in Moroccan women. Med Oncol. 2016; 33(7). doi: 10.1007/s12032-016-0784-2
Received
of 9665 breast cancer patients and 244768 controls. Asia Pac J Clin Oncol. 2014; 10(2): 101–8. doi: 10.1111/ajco.12083
2. Wolpin BM, Chan AT, Hartge P, Chanock SJ, Kraft P, Hunter DJ, et al. ABO blood group and the risk of pancreatic cancer. J Natl
Cancer Inst. 2009; 101(6): 424–31. doi: 10.1093/jnci/djp020
3. Ben Q, Wang K, Yuan Y, Li Z. Pancreatic cancer incidence and outcome in relation to ABO blood groups among Han Chinese
patients: A case-control study. Int J Cancer. 2011; 128(5): 1179–86. doi: 10.1002/ijc.25426
4. Poole EM, Gates MA, High BA, Chanock SJ, Cramer DW, Cunningham JM, et al. ABO blood group and risk of epithelial ovarian
cancer within the Ovarian Cancer Association Consortium. Cancer Causes Control. 2012; 23(11):1805–10. doi: 10.1007/s10552-012-
0059-y.
5. INCA. Estimativa 2018. Incidência de câncer no Brasil. Instituto Nacional de Câncer José Alencar Gomes da Silva. 2017. 130 p. doi:
978-85-7318-283-5
6. Brasil. Cadernos de Atenção Básica: CCU e CA de Mama. 2013. doi: 10.1007/s13398-014-0173-7.2
7. Edgren G, Hjalgrim H, Rostgaard K, Norda R, Wikman A, Melbye M, et al. Risk of gastric cancer and peptic ulcers in relation to ABO
blood type: A cohort study. Am J Epidemiol. 2010; 172(11): 1280–5. doi: 10.1093/aje/kwq299
8. Stamatakos M, Kontzoglou K, Safioleas P, Safioleas C, Manti C, Safioleas M. Breast cancer incidence in Greek women in relation to
ABO blood groups and Rh factor. Int Semin Surg Oncol. 2009; 6(14): 1-5. doi: 10.1186/1477-7800-6-14
9. Park S, Kim KS, Kim JS, Han W, Park BW, Lee S, et al. Prognostic value of ABO blood types in young patients with breast cancer; a
nationwide study in Korean Breast Cancer Society. Med Oncol. 2017; 34(6). doi: 10.1007/s12032-017-0974-6
10. Urun Y, Utkan G, Altundag K, Arslan O, Onur H, Arslan UY, et al. ABO and Rh blood groups frequency in women with HER2
positive breast câncer. J BUON. 2012; 17(3): 457-460. PMID: 23033281
11. Klimant E, Glurich I, Mukesh B, Onitilo AA. Blood type, hormone receptor status, HER2/neu status, and survival in breast cancer:
A retrospective study exploring relationships in a phenotypically well-defined cohort. Clin Med Res. 2011; 9(3-4): 111-8. doi: 10.3121/
cmr.2011.907
12. Soro anti-A, anti-B, anti-AB: anticorpos monoclonais para tipagem sanguínea. Resp. Téc.: Dra.Nadjara Novaes Longen. São Paulo
(SP): Ebram Produtos Laboratoriais Ltda, 2016.
13. Bothou A, Tsikouras P, Zervoudis S, Tsatsaris G, Anastasopoulos G, Latrakis G, et al. Bloof groups type linked to breast cancer in a
Greek cohort of women – a case control study. J BUON. 2019; 24 (5); 1884-8. PMID: 31786851
14. Rummel SK, Ellswhorth RE. The role of the histoblood ABO group in cancer. Future Sci OA. 2016;2(2). doi: 10.4155/fsoa-2015-0012
15. Franchini M, Lippi G. The intriguing relationship between the ABO blood group, cardiovascular disease, and cancer. BMC Med.
2015; 13:7. doi: 10.1186/s12916- 014-0250-y
16. Aird I, Benatll HH, Roberts JAF. Relationshio Between Cancer of Stomach and the ABO Blood Groups. Br Med J. 1953; 1(4814):799-801. doi: 10.1136/bmj.1.4814799
17. Aly R, Yousef A, Elbably O. Association of ABO Blood Group and Risk of Breast Cancer. J Blood Disords Transf. 2014; 5: 9. doi:
10.4172/2155-9864.1000241
18. Akin S, Altundag K. Clinical Associations with ABO Blood Group and Rhesus Blood Group Status in Patients with Breast Cancer:
A Nationwide Retrospective Study of 3,944 Breast Cancer Patients in Turkey. Med Sci Monit. 2018; 24: 4698- 4703. doi: 10.12659/
MSM.909499
19. Pendu JL, Marionneau S, Cailleau-Thomas A, Rocher J, Moullac-Vaidye BL, Clément B. ABH and Lewis histo-blood group antigens
in cancer. Apmis. 2001;109 (1): 9–31. doi: 10.1111/j.1600-0463.2001.tb00011.x
20. Liumbruno GM, Franchini M. Hemostasis, cancer, and ABO blood group: The most recent evidence of association. J Thromb
Thrombolysis. 2014; 38(2): 160–6. doi: 10.1007/s11239-013-1027-4
21. Yu J, Gao F, Klimberg SV, Margenthaler JA. ABO blood type/Rh factor and the incidence and outcomes for patients with triplenegative
breast cancer. Ann Surg Oncol. 2012; 19(10): 3159–64. doi: 10.1245/s10434-012-2533-x
22. Gates MA, Xu M, Chen WY, Kraft P, Hankinson SE, Wolpin BM. ABO blood group and breast cancer incidence and survival. Int J
Cancer. 2012; 130(9): 2129- 37. doi: 10.1002/ijc.26220
23. Flavarjani AHM, Hedayatpour B, Bashardoost N, Nourian SM. Study of the association between blood types and breast cancer
among Isfahanian women with breast cancer. Adv Biomed Res. 2014; 3:43. doi: 10.4103/2277-9175.125749
24. Meo AS. Blood Groups and Breast Cancer. Pak J Med Sci. 2018; 34(6): 1589. doi: 10.12669/pjms.346.16824.
25. Meo SA, Suraya F, Jamil B, Rouq FA, Meo AS, Sattar K, Ansari M, et al. Association of ABO Blood Group and Risk of Breast Cancer.
Saudi J Biol Sci. 2017; 24(7): doi: 10.1016/j.sjbs.2017.01.058
26. Vasan SK, Hwang J, Rostgaard K, Nyrén O, Ullum H, Pedersen OBV, et al. ABO blood group and risk of cancer: A register-based
cohort study of 1.6 million blood donors. Cancer Epidemiol. 2016; 44: 40–3. doi: 10.1016/j.canep.2016.06.005
27. Zouine S, Marnissi F, Otmani N, Othmani MB, Wafi ME, Kojok K, et al. ABO blood groups in relation to breast carcinoma incidence
and associated prognostic factors in Moroccan women. Med Oncol. 2016; 33(7). doi: 10.1007/s12032-016-0784-2
Received
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Published
2020-10-01
How to Cite
de Oliveira Alves, W. ., Marinho Batista Tavares Filho, R. ., Rios de Larrazábal, B. ., Elaine Silva Germinio, J. ., Lucia Peres de Medeiros, A., & Andrade Martins Esteves, F. (2020). Blood type evaluation in breast cancer patients at an oncology center in Agreste Pernambucano: DOI: 10.15343/0104-7809.202044565571. O Mundo Da Saúde, 44, 565–571. Retrieved from https://revistamundodasaude.emnuvens.com.br/mundodasaude/article/view/992
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