Inducible clindamycin resistance in cinical isolates of Staphylococcus aureus

DOI: 10.15343/0104-7809.20094401405

Abstract

Clinical failure of clindamycin therapy has been reported due to multiple mechanisms that confer resistance to macrolide,
lincosamide and streptogramin antibiotics. This study was undertaken to detect the presence of inducible clindamycin resistance among
clinical isolates of Staphylococcus aureus, by D-test, using erythromycin and clindamycin disks as per CLSI, and its relationship to oxacilin
resistance. In this study, 79,06% of MRSA presented the phenotype MLSBc, and 4,65% the phenotype MLSBi, and 2,88% and 6,73%
of MSSA, respectively. The resistance to MLS group and constitutive expression were more common among the MRSA isolates, and the
MLSBi frequency was higher in MSSA than MRSA. The inducible phenotype can compromise the clindamycin efficacy, therefore both
the inducible test and the constant monitoring of susceptibility to this drug in the S. aureus isolates are recommended, considering the
necessity of epidemiology control and therapy.