Quality of life in hematopoietic stem cell transplantation during the Covid-19 pandemic: case series

Authors

DOI:

https://doi.org/10.15343/0104-7809.202448e16112024P

Keywords:

Quality of Life, Hematopoietic Stem Cell Transplantation, COVID-19, Caregivers, Adult Health

Abstract

Hematopoietic Stem Cell Transplantation is a complex treatment, aimed at curing malignant and benign diseases, which directly affects the quality of life of patients and caregivers. Studies prior to the pandemic period presented aspects of caregiver burden and quality of life for both; this current research contributes to this gap on the topic during the pandemic. To evaluate and correlate the quality of life of hematopoietic stem cell transplant recipients with the quality of life and caregiver burden during the COVID-19 pandemic. Case series with 16 dyads, carried out in a public hospital in Brazil, a reference in Latin America. The quality of life of transplant recipients was assessed with the Functional Assessment Cancer Therapy-Bone Marrow Transplantation, caregivers with the Medical Outcomes Studt 36-Item Short Form Health Survey, burden with the Zarit Burden Interview. There was a lower perception of the functional well-being of transplant recipients and a worse general health status of caregivers; the caregiver's mental health interfered in different domains of quality of life; there was a negative correlation between quality of life and caregiver burden. The pandemic impacted the dyads’ quality of life; there is a need for additional support for both the patient and the caregiver.

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References

Oliveira C, et al. Transplante Alogênico de Células-Tronco Hematopoiéticas (TCTH) para tratamento de doença falciforme (Df): Estratégias e complicações distintas, mas resultados semelhantes com TCTH Haploidêntico (Haplo) e irmão HLA-Idêntico. Hematol Transfus Cell Ther [Internet]. 2021. [cited 2024 Jul 06]; 43:S302. Available from:: https://doi.org/10.1016/j.htct.2021.10.511.

Rasheed W, Niederwieser DW, Aljurf M. The HSCT Unit. In: Carreras, E., Dufour, C., Mohty, M., Kröger, N. (eds) The EBMT Handbook. Springer, Cham.[Internet]. 2019. [cited 2024 Jul 4]; p. 27–34. Available from: https://doi.org/10.1007/978-3-030-02278-54.

Machado, CAM, et al. Coping Religioso/Espiritual e Qualidade de Vida dos Sobreviventes de Câncer Cinco Anos após o Transplante de Células-Tronco Hematopoiéticas. Rev. Bras. Cancerol [Internet]. 2022[cited 2024 Jul 06]; 68(4):e-182812. Available from: https:// doi.org/10.32635/2176-9745.RBC.2022v68n4.2812

Rozwadowski M, et al. Promoting health and well-being through mobile health technology (Roadmap 2.0) in family caregivers and patients undergoing Hematopoietic Stem Cell Transplantation: Protocol for the development of a mobile randomized controlled trial. JMIR Res Protoc.[Internet]. 2020[cited 2024 Jul 06]; Sep 18;9(9):e19288. Available from: https://doi.org/10.2196/19288.

Posluszny DM, et al. Rates and predictors of nonadherence to the Post-Allogeneic Hematopoietic Cell Transplantation medical regimen in patients and caregivers. Transplant Cell Ther.[Internet]. 2022; [cited 2024 Jul 06]; Mar;28(3):165.e1-165.e9. Available from: https://doi.org/10.1016/j.jtct.2021.11.020

Pan Y-C, Lin Y-S. Systematic review and meta-analysis of prevalence of depression among caregivers of cancer patients. Front Psychiatry [Internet].2022[cited 2024 Jul 06]; 13: 817936. Available from: https://doi.org/10.3389/fpsyt.2022.817936

Oshiro NN, Nogueira LA, Santos YH, Guimarães PRB, Kalinke LP. Quality of life and financial toxicity of hematopoietic stem cell transplant recipients in COVID-19. Rev Lat Am Enfermagem [Internet]. 2023[cited 2024 Jul 06];31:e3996 . Available from: https://doi. org/10.1590%2F1518-8345.6688.3996

Murad MH, Sultan S, Haffar S, Bazerbachi F. Methodological quality and synthesis of case series and case reports. BMJ Evid Based Med [Internet]. 2018 Apr;23(2):60-63. Available from: https://doi.org/10.1136/bmjebm-2017-110853

Yildiz Kabak V, Atasavun Uysal S, Duger T. Screening supportive care needs, compliance with exercise program, quality of life, and anxiety level during the COVID-19 pandemic in individuals treated with hematopoietic stem cell transplantation. Support Care Cancer [Internet]. 2021[cited 2024 Jul 06]; Jul;29(7):4065–73. Available from: https://doi.org/10.1007/s00520-020-05965-1

McQuellon RP, et al. Quality of life measurement in bone marrow transplantation: development of the Functional Assessment of Cancer Therapy-Bone Marrow Transplant (FACT-BMT) scale. Bone Marrow Transplant [Internet]. 1997[cited 2024 Jul 06]; Feb;19(4):357–68. Available from: https://doi.org/10.1038/sj.bmt.1700672

Saris-Baglama RN, et al. QualityMetric health outcomesTM scoring software 4.0: installation guide. Lincoln Qual Inc. 2010.

Hébert R, Bravo G, Préville M. Reliability, Validity and Reference Values of the Zarit Burden Interview for Assessing Informal Caregivers of Community-Dwelling Older Persons with Dementia. Can J Aging [Internet]. 2000[cited 2024 Jul 06];19(4):494–507. Available from: https://psycnet.apa.org/doi/10.1017/S0714980800012484

King MT. The interpretation of scores from the EORTC quality of life questionnaire QLQ-C30. Qual Life Res [Internet]. 1996[cited 2024 Jul 06];5:555–67. Available from: https://doi.org/10.1007/bf00439229

Schober P, Boer C, Schwarte LA. Correlation coefficients: Appropriate use and interpretation. Anesth Analg [Internet]. 2018[cited 2024 Jul 06];126(5):1763–8. Available from: https://doi.org/10.1213/ane.0000000000002864

Amonoo HL, et al. Distress in a pandemic: Association of the coronavirus disease-2019 pandemic with distress and quality of life in hematopoietic stem cell transplantation. Transplant Cell Ther [Internet]. 2021[cited 2024 Jul 06]; Dec;27(12):1015.e1-1015.e7. Available from: https://doi.org/10.1016/j.jtct.2021.09.001

Chopra M, et al. Randomized controlled trial of Isha Kriya versus observation to improve quality of life in hematopoietic cell transplantation recipients. Transplant Cell Ther [Internet]. 2023[cited 2024 Jul 06];29(8):530.e1-530.e5. Available from: https://doi. org/10.1016/j.jtct.2023.05.010

Marques ACB, Szczepanik AP, Machado CAM, Santos PND, Guimarães PRB, Kalinke LP. Hematopoietic stem cell transplantation and quality of life during the first year of treatment. Rev Lat Am Enfermagem [Internet]. 2018[cited 2024 Jul 06]; 26: e3065. Available from: https://doi.org/10.1590/1518-8345.2474.3065

Knight JM, et al. Biobehavioral implications of Covid-19 for transplantation and cellular therapy recipients. Front Immunol [Internet]. 2022[cited 2024 Jul 06];13: 877558. Available from: https://doi.org/10.3389/fimmu.2022.877558

Amonoo HL, et al. Sharing and caring: The impact of social support on quality of life and health outcomes in hematopoietic stem cell transplantation. Cancer [Internet]. 2021[cited 2024 Jul 06];127(8):1260–5. Available from: https://doi.org/10.1002/cncr.33455

Yang G, Zhang H, Yang Y. Challenges and countermeasures of integrative cancer therapy in the epidemic of COVID-19. Integr Cancer Ther [Internet]. 2020[cited 2024 Jul 06]; Available from: https://doi.org/10.1177/1534735420912811

Lyon D. COVID-19, Cancer, and Financial Toxicity. Oncol Nurs Forum [Internet].2020[cited 2024 Jul 06]; 47(3):253-4. Available from: https://doi.org/10.1188/20.onf.253-254

Tan K, Fredrickson B, Santos H, Wood W, Schwartz T, Mayer D. Psychological processing among caregivers of allogeneic bone marrow transplant recipients: Qualitative findings from a longitudinal study. J Psychosoc Oncol [Internet]. 2023[cited 2024 Jul 06]; May 4;41(3):321–36. Available from: https://doi.org/10.1080/07347332.2022.2107467

Monteiro JKMF, Sá SPC, Bezerra DRC, Borges WD. Recomendações aos cuidadores e familiares de idosos mediante o COVID-19. Res Soc Dev [Internet]. 2020[cited 2024 Jul 06];9(11):e4039119798. Available from: http://dx.doi.org/10.33448/rsd-v9i11.9798

Winterling J, Kisch A, Alvariza A, Årestedt K, Bergkvist K. Preparedness for family caregiving prior to allogeneic hematopoietic stem cell transplantation. Palliat Support Care [Internet]. 2022[cited 2024 Jul 06];20(4):519–26. Available from: https://doi.org/10.1017/ s1478951521001346

Kisch AM, Bergkvist K, Alvariza A, Årestedt K, Winterling J. Family caregivers’ support needs during allo-HSCT—a longitudinal study. Support Care Cancer [Internet]. 2021[cited 2024 Jul 06];29(6):3347–56. Available from: https://doi.org/10.1007%2 Fs00520-020-05853-8

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Published

2024-07-31

How to Cite

Oshiro, N. N., Nogueira, L. de A., Marcon, S. S., Silva, L. dos S., Miranda, A. G. de, Guimarães, P. R. B., & Kalinke, L. P. (2024). Quality of life in hematopoietic stem cell transplantation during the Covid-19 pandemic: case series. O Mundo Da Saúde, 48. https://doi.org/10.15343/0104-7809.202448e16112024P

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Vol. 48 (2024): O Mundo da Saúde

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