Use of antibiotics by hospitalized elderly and changes in serum creatinine

DOI: 10.15343/0104-7809.202044126133

Authors

  • Fabiane Cristina Costa Universidade Federal de São João del-Rei - UFSJ. São João del-Rei/MG, Brasil
  • Matheus Araújo Assis Viudes Universidade Federal de Juiz de Fora - UFJF. Juiz de Fora/ MG, Brasil
  • Josiane Moreira da Costa Faculdade de Farmácia - Universidade Federal de Minas Gerais. Belo Horizonte/MG, Brasil

Keywords:

Aged; Anti-Bacterial Agents; Prescriptions; Creatinine; Renal Insufficiency.

Abstract

The rapid growth of the elderly population, associated with longer life expectancy, is associated with a higher prevalence
of chronic non-communicable diseases, such as those of the cardiovascular, renal system and neoplasms. A large portion
of these pathologies require hospitalization and their conditions require the use of antibiotics (ATB), whose indiscriminate
use can lead to Acute Kidney Injury (AKI), which has serum creatinine as one of its markers. Therefore, the present study
aimed to evaluate changes in serum creatinine of hospitalized elderly people submitted to antibiotic therapy in a university
hospital. This was a cross-sectional study in which patients over 60 years old were identified during a period of 6 months
and who used ATB, as well as had their serum creatinine measured. The variables age, gender, length of hospital stays and
use of ATB were considered, as well as serum creatinine values before and after antibiotic therapy. A total of 796 patients
participated in the study, 51.4% (409) of whom were male. Ages ranged from 60 to 109 years, with an average of 74.9 (±
9.6). It was identified that length of stay and use of ATB are variables that interfere with the increase in creatinine due to
antibiotic therapy, which was observed in 75.5% of the patients. This leads to the reflection about a possible indiscriminate
prescription of antimicrobials and their correlation to AKI.

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Published

2020-01-01

How to Cite

Cristina Costa, F., Araújo Assis Viudes, M., & Moreira da Costa, J. . (2020). Use of antibiotics by hospitalized elderly and changes in serum creatinine: DOI: 10.15343/0104-7809.202044126133. O Mundo Da Saúde, 44, 126–133. Retrieved from https://revistamundodasaude.emnuvens.com.br/mundodasaude/article/view/943