Ecotoxicological assessment of four pharmaceuticals compounds through acute toxicity tests

DOI: 10.15343/0104-7809.20143801051055

Authors

  • Flávia Junqueira de Castro Instituto de Pesquisas Energéticas e Nucleares – IPEN, São Paulo-SP, Brasil.
  • Dymes Rafael Alves dos Santos Instituto de Pesquisas Energéticas e Nucleares – IPEN, São Paulo-SP, Brasil.
  • Caio Roberto Picolomini Buongermino Instituto de Pesquisas Energéticas e Nucleares – IPEN, São Paulo-SP, Brasil.
  • Fernando Sanzi Cortez Universidade Santa Cecília, Santos-SP, Brasil.
  • Camilo Dias Seabra Pereira Universidade Federal de São Paulo – UNIFESP, Santos-SP, Brasil.
  • Rodrigo Brasil Choeri Universidade Federal de São Paulo – UNIFESP, Santos-SP, Brasil.
  • Augusto Cesar Universidade Federal de São Paulo – UNIFESP, Santos-SP, Brasil.

Keywords:

Estrogens. Serotonin Uptake Inhibitors. Anti-Inflammatory Agents. Analgesics. Toxicity.

Abstract

In this study, we evaluated acute toxicity of four different pharmaceutical compounds: 17 α-ethinylestradiol (EE2), fluoxetine,
diclofenac and ibuprofen to Daphnia similis. The average values of EC50 were 1.63 mg/L to the 17α-ethinylestradiol
(EE2), 4.41 mg/L to the fluoxetine, 46.0 mg/L to the diclofenac and 97.0 mg/L to the ibuprofen. The effects of these drugs,
in particular those caused to aquatic biota, still unknown especially at low concentrations in a range from ng/L up to mg/L.

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Published

2014-01-01

How to Cite

Junqueira de Castro, F. ., Alves dos Santos, D. R. ., Picolomini Buongermino, C. R., Sanzi Cortez, F., Dias Seabra Pereira, C. ., Brasil Choeri, R. ., & Cesar, A. . (2014). Ecotoxicological assessment of four pharmaceuticals compounds through acute toxicity tests: DOI: 10.15343/0104-7809.20143801051055. O Mundo Da Saúde, 38(1), 51–55. Retrieved from https://revistamundodasaude.emnuvens.com.br/mundodasaude/article/view/401

Issue

Vol. 38 No. 1 (2014): JANUARY/MARCH 2014

Section

Articles